Male and female caffeine consumption ups miscarriage risk—study

WASHINGTON—Women have an increased risk of miscarriage if they or their partner consume more than two caffeinated drinks a day in the weeks leading up to conception, a new US study found.

Women who drink more than two caffeinated beverages per day during the first seven weeks of pregnancy were also more likely to have a miscarriage, according to the study published online late Thursday in the journal Fertility and Sterility.

But rates of miscarriage are reduced for women who take a daily multivitamin before and after conception.

The study, carried out by researchers from the National Institutes of Health and Ohio State University, was based on data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study.

That study followed 501 couples in Michigan and Texas from 2005 to 2009, examining the relationship between fertility, lifestyle and exposure to chemicals in the environment.

The current study compared cigarette use, caffeinated beverage consumption and multivitamin use among 344 couples when the woman was carrying a single offspring. Of these pregnancies, 98 — or 28 percent — ended in miscarriage.

The researchers’ conclusions were based on a statistical concept called hazard ratio, which estimates the chances of a particular outcome occurring during the study period.

A ratio greater than one indicates increased risk for miscarriage each day following conception, while a ratio less than one indicates reduced daily risk.

The risk of miscarriage was 1.74 when the woman consumed more than two caffeinated drinks a day, the study showed.

However, the risk was almost as high — 1.73 — if the male partner drank that much caffeine or more.

“Our findings also indicate that the male partner matters, too,” said lead author Germaine Buck Louis, director of the Division of Intramural Population Health Research at the NIH. “Male preconception consumption of caffeinated beverages was just as strongly associated with pregnancy loss as females’.”

The study also found that taking a daily multivitamin significantly reduced chances of miscarriage.

Taking a vitamin in the weeks leading up to conception had a hazard ratio of 0.45, a 55 percent reduction in risk for pregnancy loss.

Women who continued to take multivitamins through the early stages of pregnancy had a hazard ratio of 0.21, a risk reduction of 79 percent.

source: technology.inquirer.net

Drinking coffee may lower risk of multiple sclerosis

WASHINGTON - People who drink four to six cups of coffee daily may be less likely to get multiple sclerosis, according to international research out Thursday.

"Caffeine intake has been associated with a reduced risk of Parkinson's and Alzheimer's diseases," said lead author Ellen Mowry of the Johns Hopkins University School of Medicine in Baltimore, Maryland.

"Our study shows that coffee intake may also protect against MS, supporting the idea that the drug may have protective effects for the brain," she added.

The findings of a US and Swedish study—released ahead of the American Academy of Neurology annual meeting in Washington—each compared more than 1,000 MS patients to a similar number of healthy people.

Researchers tracked how much coffee the subjects drank in the one, five and 10 years before symptoms began for those afflicted with MS.

After accounting for other factors such as age, sex, smoking, body mass index and sun exposure, the Swedish study found that "compared to people who drank at least six cups of coffee per day during the year before symptoms appeared, those who did not drink coffee had about a one and a half times increased risk of developing MS."

Similar protective effects were seen among those who drank lots of coffee five to 10 years before symptoms appeared.

The US study found that "people who didn't drink coffee were also about one and a half times more likely to develop the disease than those who drank four or more cups of coffee per day in the year before symptoms started to develop."

More research is needed to determine if caffeine in coffee has any impact on relapse or long-term disability due to MS, an incurable disease of the central nervous system that affects 2.3 million people worldwide.

The study was funded by the Swedish Medical Research Council, the US National Institute of Neurological Disorders and Stroke, the National Institute of Environmental Health Sciences and the National Institute on Aging. — Agence France-Presse

source: gmanetwork.com