Showing posts with label Scientists. Show all posts
Showing posts with label Scientists. Show all posts
Thursday
Cancer researchers accidentally discover cure for baldness, gray hair
A group of scientists from the UT Southwestern Medical Center in Dallas, Texas, were set on discovering how cancer tumors form.
But in the process of doing so, the team found a genetic cure for baldness and hair graying.
According to a report from The Sun, the breakthrough was made possible after multiple cellular experiments with lab mice.
After certain cells were removed, the mice became bald, while deleting a gene in the cells turned its hair white.
“Although this project was started in an effort to understand how certain kinds of tumors form, we ended up learning why hair turns gray and discovering the identity of the cell that directly gives rise to hair,” said Dr. Lu Le, associate professor of dermatology at UT Southwestern Medical Center.
“With this knowledge, we hope in the future to create a topical compound or to safely deliver the necessary gene to hair follicles to correct these cosmetic problems,” he added.
Furthermore, the study revealed that the protein called KROX20—a vital key in nerve development—was primarily responsible for turning skin cells into hair follicles.
The group’s findings were recently published in the Genes and Development journal. Khristian Ibarrola /ra
source: technology.inquirer.net
Monday
Scientists discover seaweed that tastes like bacon
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Researchers from the Hatfield Marine Science Center claim they’ve come up with the next superfood—a new type of seaweed that tastes exactly like bacon and could rival kale in terms of health benefits.
According to a TIME report, the tasty creation of red marine algae called “dulse” appears much like the typical red lettuce, but is actually packed full of minerals and protein.
The patented underwater herb usually grows in the wild along the Pacific and Atlantic coastlines and is harvested, dried and normally sold as a cooking ingredient or nutritional supplement.
“Dulse is a superfood, with twice the nutritional value of kale,” said Chuck Toombs, an OSU faculty and member of the team working to develop the product into a foodstuff. “And OSU had developed this variety that can be farmed, with the potential for a new industry for Oregon.”
The team intended to focus its research on farming the new strain of dulse to feed abalone, but quickly shifted direction after realizing its potential to do well in the human-food market.
“There hasn’t been a lot of interest in using it in a fresh form. But this stuff is pretty amazing,” said chief researcher Chris Langdon.
“When you fry it, which I have done, it tastes like bacon, not seaweed. And it’s a pretty strong bacon flavor,” he added.
The Oregon Department of Agriculture is backing the idea of exploring dulse as a “special crop” and has already provided Langdon’s group with a sizable grant. The team is currently working with the Food Innovation Center in Portland, as well as several chefs, to find out ways to incorporate dulse in everyday cooking.
The US currently has no commercial operation that sanctions dulse for human consumption, but the team is optimistic that their product would be sold commercially in food markets in the near future. Khristian Ibarrola
source: technology.inquirer.net
Thursday
Chocolate's source is over 9 million years old, scientists find
The plant that we use to make chocolate diverged from its closest relative almost 10 million years ago (Ma), according to a study published in the journal Frontiers in Ecology and Evolution.
The researchers looked at Theobroma cacao, the source of chocolate, and analyzed both its chloroplasts and nuclear DNA. They found that the genus Theobroma split from the genus Herrania around 12.7 Ma, and that Theobroma had a faster rate of diversification compared to other branches in its family.
The study also found that T. cacao diversified from its “most recent common ancestor” 9.9 Ma, and said that this means that it has had a lot of time to end up with a significant diversity within its own species.
This finding means good news for the chocolate industry and agriculture—most plantations only use a small percentage of the diversity available, and this lack of variation in cultivated cacao plants means that they’re vulnerable to pests and diseases and may not be able to adapt to climate change.
“Studies of the evolutionary history of economically important groups are vital to develop agricultural industries, and demonstrate the importance of conserving biodiversity to contribute towards sustainable development,” said Dr. James Richardson, lead author of the study and a tropical botanist at the Royal Botanic Garden Edinburgh. “Here we show for the first time that the source of chocolate, Theobroma cacao, is remarkably old for an Amazonian plant species.”
The study said that wild varieties of T. cacao could be used to introduce greater diversity in plantations. — Bea Montenegro/TJD, GMA News
source: gmanetwork.com
MERS virus found in Qatar camels, linked to human spread
DOHA/LONDON - Scientists have found cases of Middle East Respiratory Syndrome (MERS) in camels in Qatar, health officials said on Thursday, fuelling speculation that camels might be the animal reservoir that allowed the virus to infect and kill humans.
The SARS-like coronavirus, which emerged in the Middle East last year and has killed almost 40 percent of the around 170 people so far infected, was found in three camels in a herd in a barn also linked to two human cases of MERS infection.
"The three camels were investigated among a herd of 14 camels, and the samples were collected as part of the epidemiological investigation," Qatar's Supreme Council of Health said in a statement.
It added that the two confirmed human cases linked to the barn had since recovered. Scientists around the world have been seeking to pin down the animal source of MERS virus infections since the first human cases were confirmed.
British researchers who conducted some of the very first genetic analyses on MERS last September said the virus, which is from the same family as Severe Acute Respiratory Syndrome, or SARS, was also related to a virus found in bats.
Confirming and commenting on the virus being found in camels in Qatar, WHO spokesman Gregory Hartl said there was still insufficient evidence to say for sure what the source of the human MERS infections was.
"Neither camels nor bats can yet be said to be reservoir of MERS," he said on the networking site Twitter.
Ab Osterhaus, a professor of virology at the Erasmus Medical Centre in The Netherlands that worked on the camel study, told Reuters the results were confirmed by a range of tests including sequencing and antibody testing.
Dutch scientists said in August they had found strong evidence that the MERS virus is widespread among one-humped dromedary camels in the Middle East - suggesting people who become infected may be catching it from camels used for meat, milk, transport and racing.
Saudi officials said this month that a camel there had tested positive for MERS a few days after its owner was confirmed to have the virus.
The World Health Organization (WHO) said in its latest MERS update on Nov. 22 that of the 176 laboratory-confirmed and probable reported human cases to date, 69 people had died.
Human cases of MERS, which can cause coughing, fever and pneumonia, have so far been reported in Saudi Arabia, Qatar, Kuwait, Jordan, United Arab Emirates, Oman, Tunisia, France, Germany, Spain, Italy and Britain.
Osterhaus, whose team worked with Qatar's Health and Environment Ministries on the study, said that, at this stage, "no more details can be disclosed" about the findings since a scientific paper was in the process of being prepared and submitted for peer review and publication.
The Qatari health council said, however, as a precaution, the elderly and people with underlying health conditions such as heart disease, diabetes and respiratory illnesses should avoid any close animal contact when visiting farms and markets. — Reuters
source: gmanetwork.com
Monday
Stem cell advance boosts prospects for retina treatment
PARIS - Blind mice have been able to see once more in a laboratory exploit that marks a further boost for the fast-moving field of retinal therapy, according to a study published on Sunday.
Scientists in Britain used stem cells—early-stage, highly versatile cells—taken from mice embryos, and cultured them in a lab dish so that they differentiated into immature photoreceptors, the light-catching cells in the retina.
Around 200,000 of these cells were then injected into the mice's retinas, some of which integrated smoothly with local cells to restore sight.
The rodents were put through their paces in a water maze and examined by optometry to confirm that they responded to light.
Embryonic stem cells "could in future provide a potentially unlimited supply of health photoreceptors for retinal transplantations to treat blindness in humans," Britain's Medical Research Council (MRC) said in a press release.
Photoreceptor loss lies behind degenerative eye diseases such as retinitis pigmentosa and age-related macular degeneration, also called AMD.
Stem cells have triggered a huge interest and investment on the back of hopes that they can become replacement tissue, grown in a lab dish, for cells damaged by disease or accident.
But the exciting field has to overcome big obstacles.
One is the ability to coax these immature cells into safely becoming the specialised cells that are needed, rather than turn cancerous.
This is where the new work marks a gain, according to lead researcher Robin Ali at the University College London Institute of Ophthalmology and Moorfields Eye Hospital.
His team previously found that sight could be restored in blind mice by transplanting immature photoreceptors called rod cells that were taken from the retinas of healthy rodents.
The latest research takes things further because the transplanted material comprises all the different nerve cells needed for sight—and they were not taken from other animals.
Instead, they were grown in a lab and differentiated into the right cells thanks to a new technique, pioneered in Japan, that replicates the shape of the retina.
"Over recent years, scientists have become pretty good at working with stem cells and coaxing them to develop into different types of adult cells and tissues," said Ali.
"But until recently, the complex structure of the retina has proved difficult to reproduce in the lab. This is probably because the type of cell culture we were using was not able to recreate the developmental process that would happen in a normal embryo."
Ali added: "The next step will be to refine this technique using human cells to enable us to start clinical trials."
The study appears in the journal Nature Biotechnology.
Last month, Japanese authorities approved proposals for the world's first clinical trials using stem cells harvested from a patient's own body.
The goal is to test therapy for AMD using so-called induced pluripotent stem cells, or iPS.
These are adult cells that have been reprogrammed to return to their infant, versatile state. Provided that they are proven safe, they can provide a non-controversial alternative to stem cells culled from early-stage embryos. —Agence France-Presse
source: gmanetwork.com
Friday
Teaching kids the history and humanity of science
Think about this the next time you look at a periodic table: Did you know that its discoverer, Dmitri Mendeleev,
once made an 11,500-foot-high solo flight in a balloon? Or that he
resigned his post at the University of St. Petersburg in support of
protests against czarist oppression in Russia?
A
chemist himself by training, Dr. Michael Purugganan says that it's more
important to teach children to understand the history and humanity
behind the periodic table rather than just having kids memorize it.
"[Memorizing is] not what science is. Science is solving problems about
the universe," he told GMA News Online in a roundtable interview.
He recalls that, when he was a young boy, he would sneak into the
premises of the old National Science Development Board in Malate and
spend hours looking at all the scientific equipment there.
"It just fascinated me. That was what really inspired me to become a
scientist," he recalls. Today, he is the Dean for Science at New York
University and a world leader in evolutionary and ecological genomics.
But it all started with that early spark of curiosity, which fueled a
lifetime of scientific exploration —a far cry from the rote method of
instruction so common in the science classroom.
Philippine science education as a whole
"People are very worried about science education," he said. "They think
it's not doing very well, so this is not only a problem in the
Philippines. How you teach science to children around the world is
something people are thinking about. For Philippines especially, I
suspect it is a problem that is across the board, not just in science
but everything."
Purugganan —who graduated from
BS Chemistry at the University of the Philippines Diliman— said that
science high schools in the Philippines provide top-notch education, but
he wished that these schools' competence in the sciences can be spread
to regular, non-specialized schools as well.
"I
think we have to enrich the curriculum and we have to focus on how we
teach. I think the way we approach science should be changed," he
suggested.
Approaches to education
Approaches to education
"I think there's enough people out there who can look at what's been
working and what's not been working. The Bernidos' school in Bohol is
doing excellent science education. They won the Magsaysay Award, and
they're doing excellent education in a rural part of Bohol and yet their
students rank in the top 10 nationwide in the mathematics exam (of the
National Career Assessment Examination). They're doing something right,"
he enthused.
Physicists Christopher and Maria
Victoria Bernido left their jobs at the National Institute in the
University of the Philippines in 1999 to revive a high school in the
remote municipality of Jagna, Bohol that was in danger of closing down.
The Bernidos introduced a unique way for learning both science and non-science subjects, called the Dynamic Learning Program, in which more than half of the class time is made up of student-driven activities rather than simple lectures from the teachers. The couple was awarded the prestigious Ramon Magsaysay Award in 2010.
The Bernidos introduced a unique way for learning both science and non-science subjects, called the Dynamic Learning Program, in which more than half of the class time is made up of student-driven activities rather than simple lectures from the teachers. The couple was awarded the prestigious Ramon Magsaysay Award in 2010.
Purugganan thinks it's good that the Philippines is soon implementing
K-12 education, but only if enrichment of the curriculum is part of this
change. For the most part, Purugganan is neutral towards the impact of
K-12 to the quality of education.
"I went
through a K-10 education. A lot of other scientists I know went through
K-10 education. It did not hurt us because we had a really good
curriculum. We know that it's worked in the past, so increasing the time
is not necessarily the answer," he said.
"I'm not sure K-12 is the answer. Hopefully it might be, if it forces policymakers to look carefully about what they're teaching throughout that K-12," he added.
"I'm not sure K-12 is the answer. Hopefully it might be, if it forces policymakers to look carefully about what they're teaching throughout that K-12," he added.
Surprise discoveries and curiosity-driven research
Purugganan says that people and the government should acknowledge that breakthroughs in science generally come unplanned.
"The one thing I learned from being in science for a long time is that
we have no idea where breakthroughs are going to come from, where things
are going to happen," he said.
"One of the
examples I give is one of the biggest technologies in the world for
genetics right now, PCR (Polymerase Chain Reaction) technology: somebody
just decided to study this bacteria that was growing in a hot spring in
Yellowstone. He was interested in what's growing in the hot spring, he
wasn't thinking of developing a new technology, but that's where this
technology came from," he shared.
Purugganan
prizes "curiosity-driven research." Scientists, according to him, must
be allowed a certain degree of freedom to pursue interests in research.
Purugganan currently runs research laboratories in New York and Abu
Dhabi and has published over 100 research papers. This experience helped
him lead several large-scale multimillion dollar international research
projects funded by the US National Science Foundation.
"We call it curiosity-driven research. This is why we let our
scientists follow their curiosity and why many countries allow
scientists to do that is because there is this understanding that we
actually can't plan where these discoveries will come from. And so we
should give scientists some freedom to pursue where their curiosity
takes them," he said.
Purugganan distinguishes
between research that needs to have an end product and those that are
more exploratory in nature. And even when an end product such as a
particular medicine is expected, it may take as long as twenty years to
be developed for mass consumption.
He clarifies:
"What I've noticed is that there is almost a requirement that at the
end of your research there will be a clear product (as if) we're gonna
change the world in five years. You see this all the time, they will ask
that in five years there's a drug that comes out of this research.
(But) in the United States, it takes about twenty years to go from
laboratory to drug. I think it's asking too much. That orientation
should be revisited."
Budgeting resources, identifying top scientists
Budgeting resources, identifying top scientists
Purugganan does acknowledge that resources for research are limited.
However, such research does not necessarily have to have a concrete
product in the end.
"We have limited
resources so we've got to be very careful about where it goes. [The
project] should be something that either the people or the government
sees has meaning, that there's something we get out of it. But it
doesn't have to be product-oriented, I think it's wrong to think that
'at the end of this research I would have Product X.' It doesn't have to
have a product in the end but it has to be relevant, and the relevance
means that it's something that would be useful to us," he said.
But how should the government set its priorities when it comes to funding scientific research?
Purugganan thinks the government should determine the top Filipino
scientists in their respective fields, and ask them what needs to be
done and why it should be done. This way, the government is able to
better utilize its homegrown scientific expertise.
"I think the better way to fund is [to ascertain] who are the good
scientists in the country and ask them 'What would you do?' and explain
what it is you need to do and why it's important," he said. "Let the
scientists come up with the ideas rather than the government imposing on
them where they should be doing research. I think that we're wasting
resources because I'm not sure it's the best use of the expertise of our
scientists. And at the end of the day I'm not sure that the goal of the
government is to solve this problem so we also have to rethink how we
do that."
Firing up kids' curiosity and passion
In his interview with GMA News Online editor-in-chief Howie Severino on
News To Go, Purugganan encouraged aspiring scientists to set their eyes
on their goal.
Filipinos who earn their degrees abroad do come back, said
Purugganan. Or at the least, they give back by getting involved in
Philippine-based projects, or by consulting and teaching.
Severino noted that this could be a way of reversing the brain drain, still an ongoing phenomenon in the country.
"Absolutely. I think we should do that. It's very important for our country to do that," Purugganan agreed.
Forwarding the quest for the Filipino Genome
As if to sum up his entire philosophy on scientific discovery and
progress, Dr. Purugganan underscored the value of pursuing the so-called
Filipino Genome.
A leader in the field of evolutionary and ecological genomics, he sits on the advisory board of the DOST's newly-built Philippine Genomics Center.
A leader in the field of evolutionary and ecological genomics, he sits on the advisory board of the DOST's newly-built Philippine Genomics Center.
"Genomics [...] focuses more on finding the application of a mapped
gene sequence through manipulation. The goal is to produce a better
animal breed, a pest-resistant crop, or an anti-infective drug for
diseases such as tuberculosis or the influenza A H1N1 virus," a
statement on the DOST website said.
Purugganan is visibly excited about the Genomics Center and the prospect of a Filipino Genome Diversity Project, and its far-reaching impact on our shared past and potential future.
One might imagine Mendeleev looking down from his balloon, nodding in approval.
— TJD, GMA NewsOne might imagine Mendeleev looking down from his balloon, nodding in approval.
Monday
Yale physicists move closer to a working quantum computer
Physicists at Yale University have devised a way to give
scientists greater control in the volatile realm of quantum mechanics by
letting them observe quantum data without disruption —an important step
towards building a working quantum computer.
A report on SciTechDaily
said the scientists developed a new, non-destructive measurement system
for observing, tracking and documenting all changes in a qubit’s state,
preserving the qubit’s informational value.
“Our experiment is a dress rehearsal for a type of process essential for
quantum computing,” said Michel Devoret, the Frederick William Beinecke
Professor of Applied Physics & Physics at Yale.
“What this experiment really allows is an active understanding of
quantum mechanics. It’s one thing to stare at a theoretical formula and
it’s another thing to be able to control a real quantum object,” he
added.
Devoret is also the principal investigator of research published Jan. 11 in the journal Science.
The SciTechDaily report said this could greatly improves the prospects
of quantum computing, with quantum computers being envisioned to be
exponentially faster than today's most powerful computers.
Other authors of the paper include S. Shankar, M. Mirrahimi, F.
Schackert, K. Geerlings, T. Brecht, K.M. Sliwa, B. Abdo, L. Frunzio,
S.M. Girvin, and R.J. Schoelkopf.
Support for
the research was provided by the National Science Foundation, the United
States Army Research Office, the Intelligence Advanced Research
Projects Activity, the Agence National de Recherche, and the College de
France.
Quantum systems
In quantum systems, microscopic units called qubits represent
information, with qubits assuming either of two states 0 or 1, or both
simultaneously.
While it is important to
recognize and track their state for quantum computing, the act of
monitoring them usually damages their information content.
But now, Yale physicists drew up a new, non-destructive measurement
system for observing, tracking and documenting all changes in a qubit’s
state, preserving the qubit’s informational value.
"In principle, the scientists said, this should allow them to monitor
the qubit’s state in order to correct for random errors," SciTechDaily
said.
“As long as you know what error process
has occurred, you can correct. And then everything’s fine. You can
basically undo the errors,” Devoret said.
Michael Hatridge, a postdoctoral associate in physics at Yale and lead
author of the Science paper, added this is the key - “the ability to
talk to the qubit and hear what it’s telling you.”
“A major problem with quantum computing is the finite lifetime of
information stored in the qubits, which steadily decays and which must
be corrected. We now know that it is possible to do this correction by
feedback involving a continuous measurement. Our work advances the
prospects of large-scale quantum computers by opening the door to
continuous measurement-based quantum feedback,” he said.
The Yale physicists have successfully measured one qubit, but now the challenge is to measure and control many at once.
For now, the team is developing ultra-fast digital electronics for this purpose.
“We are on the threshold between the ability to measure and control one or two qubits, and many,” Hatridge said. — TJD, GMA News
source: gmanetwork.com
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